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KMID : 1137020070180040299
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Journal of Gynecologic Oncology
2007 Volume.18 No. 4 p.299 ~ p.307
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Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer
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Kim Sung-Hee
Moon Soo-Hyeon
Shin Su-Il
Suh Dong-Soo
Yoon Man-Soo
Choi Kyung-Un
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Abstract
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Objective: To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining.
Methods: Tissue samples (n=72) were collected after staging operation between 1998 and 2004.
Results: In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI).
Conclusion: We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.
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KEYWORD
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Epithelial ovarian cancer, Rb pathway alteration, E2F-1 expression
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